{"id":915,"date":"2022-05-01T13:23:53","date_gmt":"2022-05-01T04:23:53","guid":{"rendered":"https:\/\/tomitaph.co.jp\/home\/products\/apatite-and-calcium-phosphate\/"},"modified":"2024-11-04T11:45:59","modified_gmt":"2024-11-04T02:45:59","slug":"biomaterials-hydroxyapatite","status":"publish","type":"page","link":"https:\/\/tomitaph.co.jp\/en\/products\/biomaterials-hydroxyapatite\/","title":{"rendered":"Biomaterials Hydroxyapatite"},"content":{"rendered":"\n<section class=\"l-bgfff-base products-detail-page\">\n          <div class=\"l-contents\">\n            <article class=\"endmargin\">\n              <section class=\"endmargin\">\n                <h1 class=\"title-level2 font-serif\">Biomaterials Hydroxyapatite<\/h1>\n                <h2 class=\"title-level3__product\" style=\"margin-bottom:60px;\">Inorganic materials for the biomaterials field<\/h2>\n                <h4 class=\"sub_title\"><span>Hydroxyapatite<span><\/h4>\n              <ul class=\"list_dot\">\n              <li>Hydroxyapatite is basic calcium phosphate and exists naturally as a major component of bones and teeth and as an ore in nature.<\/li>\n              <li>Hydroxyapatite shows high biocompatibility and is utilized in biomaterials such as artificial bones, dental implants, and coating materials for artificial joints.<\/li>\n              <li>Tomita Pharmeceuticals&#8217; hydroxyapatite conforms to ASTM* standards, and in addition to meeting standards for quality and impurities as raw material for medical equipment, its physical properties are strictly controlled according to the requirements of each application.<\/li>\n              <li>Since impurities are controlled and managed during production, there are few elemental and crystalline structural impurities, resulting in high purity.<\/li>\n              <li>It therefore inherently has a high degree of whiteness, making it ideal for products with a white coating.<\/li>\n              <\/ul>\n\t\t\t\t\t<p><small>*ASTM standards are developed and published by ASTM International (formerly known as the American Society for Testing and Materials), the world&#8217;s largest standards organization.<\/small><\/p>\n\t\t\t  <\/section>\n<p class=\"table_title\">\n  <ul class=\"list_dot\">\n    <li>Chemical name: Hydroxyapatite (tricalcium phosphate)<\/li>\n    <li>Chemical composition: Ca<sub class=\"small\">10<\/sub>(PO<sub class=\"small\">4<\/sub>)<sub class=\"small\">6<\/sub>(OH)<sub class=\"small\">2<\/sub>&ensp;CAS No. 1306-06-5<\/li>\n  <\/ul>\n<\/p>\n<div class=\"over-x\">\n<table class=\"productlist productlist6 no_hover tbl-hyd\">\n  <tr>\n    <th>Product Name<\/th>\n    <th colspan=\"2\">Use<\/th>\n    <th>Characterstics<\/th>\n  <\/tr>\n  <tr>\n    <td>Hydroxyapatite C<\/td>\n    <td rowspan=\"3\" style=\"vertical-align: middle;\">For industrial use<\/td>\n    <td rowspan=\"3\" style=\"vertical-align: middle;\">Abrasives, materials for plasma thermal spraying, <br>raw materials for biomaterials <br>(artificial bone, dental implants, bone filler)<\/td>\n    <td rowspan=\"3\" style=\"vertical-align: middle;\">\n      <ul class=\"list_dot table_list\">\n        <li>Capable of coating PEEK and Ti alloys<\/li>\n        <li>Lineup based on physical properties<\/li>\n        <li>Spherical granule type<\/li>\n        <li>ISO\/ASTM compliant<\/li>\n      <\/ul>\n    <\/td>\n  <\/tr>\n  <tr>\n    <td>Hydroxyapatite HD<\/td>\n  <\/tr>\n  <tr>\n    <td>Hydroxyapatite FP<\/td>\n  <\/tr>\n<\/table>\n<\/div>\n\n\n\n<div class=\"contentBox\">\n  <h4 class=\"sub_title\"><span>Hydroxyapatite for Thermal Spraying<\/span><\/h4>\n  <div class=\"textContent\">\n    <p>\n      Our hydroxyapatite conforms to ISO13779-6. Since medical devices such as implants exist in the body for a long period of time, elemental impurities and analogous substances in their raw materials must be strictly controlled.<br>\n\t  We strictly control hydroxyapatite from raw materials to manufacturing and quality inspection, and can provide products that qualify as raw materials for medical equipment as well as conforming to ISO.\n    <\/p>\n  <\/div><!-- \/.textContent -->\n  <div class=\"column_2\">\n      <div class=\"textcoutent\">\n        <p class=\"table_title\">Physical properties<\/p>\n<div class=\"over-x\">\n        <table class=\"tablelist productlist productlist5\">\n          <thead>\n            <tr class=\"tr1\">\n              <th rowspan=\"2\" style=\"border-left:none;\" colspan=\"2\" class=\"row_center text_center\">Test case<\/th>\n              <th colspan=\"3\" class=\"text_center\">Example of Analysis<\/th>\n            <\/tr>\n            <tr>\n              <th>Hydroxyapatite C<\/th>\n              <th>Hydroxyapatite HD<\/th>\n              <th>Hydroxyapatite FP<\/th>\n            <\/tr>\n          <\/thead>\n          <tbody>\n            <tr>\n              <th class=\"th1\" colspan=\"2\">Bulk density(ISO 3923-1)<\/th>\n              <td>0.5 g\/mL<\/td>\n              <td>0.8 g\/mL<\/td>\n              <td>1.0 g\/mL<\/td>\n            <\/tr>\n            <tr>\n              <th rowspan=\"3\" class=\"th1 row_center\">Particle size distribution<\/th>\n              <th>D<span class=\"text_wrap\">10<\/span><\/th>\n              <td>57 \u03bcm<\/td>\n              <td>57 \u03bcm<\/td>\n              <td>15 \u03bcm<\/td>\n            <\/tr>\n            <tr>\n              <th>D<span class=\"text_wrap\">50<\/span><\/th>\n              <td>91 \u03bcm<\/td>\n              <td>93 \u03bcm<\/td>\n              <td>28 \u03bcm<\/td>\n            <\/tr>\n            <tr>\n              <th>D<span class=\"text_wrap\">90<\/span><\/th>\n              <td>150 \u03bcm<\/td>\n              <td>156 \u03bcm<\/td>\n              <td>48 \u03bcm<\/td>\n            <\/tr>\n          <\/tbody>\n        <\/table>\n<\/div>\n      <\/div><!-- \/.textcoutent -->\n      <div class=\"textContent\">\n        <p class=\"table_title\">SEM image<\/p>\n        <table class=\"tablelist productlist productlis_img\">\n          <tr>\n            <th>Hydroxyapatite C<\/th>\n              <th>Hydroxyapatite HD<\/th>\n              <th>Hydroxyapatite FP<\/th>\n          <\/tr>\n          <tr>\n            <td><img decoding=\"async\" src=\"\/home\/wp-content\/uploads\/2022\/05\/hydroxyapatite-c.jpg\" alt=\"Hydroxyapatite C\"><\/td>\n            <td><img decoding=\"async\" src=\"\/home\/wp-content\/uploads\/2022\/05\/hydroxyapatite-hd.jpg\" alt=\"Hydroxyapatite HD\"><\/td>\n            <td><img decoding=\"async\" src=\"\/home\/wp-content\/uploads\/2022\/05\/hydroxyapatite-fp.jpg\" alt=\"Hydroxyapatite FP\"><\/td>\n          <\/tr>\n        <\/table>\n      <\/div><!-- \/.textContent -->\n  <\/div><!-- \/.column_2 -->\n<\/div><!-- \/.contentBox -->\n\n\n\n<div class=\"contentBox\">\n  <h4 class=\"sub_title\"><span>Example of application as a coating material<\/span><\/h4>\n  <div class=\"textContent\">\n    <p>We performed plasma thermal spraying experiments to confirm the coating characteristics of our hydroxyapatite on Poly Ether Ether Ketone (PEEK), which is used as a base material for implants.<\/p>\n  <\/div><!-- \/.textContent -->\n  <div class=\"column_2\">\n      <div class=\"textcoutent\">\n        <p class=\"table_title\">Test conditions<\/p>\n        <table class=\"tablelist productlist productlist7\" style=\"max-width:950px;\">\n          <thead>\n            <tr class=\"tr1\">\n              <th colspan=\"3\">Test Case<\/th>\n              <th>Conditions<\/th>\n            <\/tr>\n          <\/thead>\n          <tbody>\n            <tr>\n              <th class=\"th1\" colspan=\"3\" style=\"text-align:left;\">Thermal Spraying Method<\/th>\n              <td>Atmosphere Plasma Spray<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1\" colspan=\"3\">Base Material<\/th>\n              <td>PEEK<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\" colspan=\"3\">Coating Material<\/th>\n              <td>\n                <ul class=\"list_dot table_list\">\n                  <li>Hydroxyapatite FP<\/li>\n                  <li>Competitor product<\/li>\n              <\/ul>\n            <\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\" colspan=\"2\" rowspan=\"3\">Blasting conditions<\/th>\n              <th>Media<\/th>\n              <td>Al2O3 (WA\u266f46)<\/td>\n            <\/tr>\n            <tr>\n              <th>Pressure<\/th>\n              <td>0.5 MPa<\/td>\n            <\/tr>\n            <tr>\n              <th>Distance<\/th>\n              <td>150 mm<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\" colspan=\"3\">Thermal Spray Equipment<\/th>\n              <td>\n                <ul class=\"list_dot table_list\">\n                  <li>GTV\/MF-P<\/li>\n                  <li>HVOF-K1000<\/li>\n                  <li>Plasma Torch Typ F4<\/li>\n              <\/ul>\n            <\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\" rowspan=\"2\">Working gas<\/th>\n              <th class=\"th2\">Ar<\/th>\n              <th>SLPM<\/th>\n              <td>30<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th2\">He<\/th>\n              <th>SLPM<\/th>\n              <td>150<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\">Carrier gas<\/th>\n              <th class=\"th2\">N2<\/th>\n              <th>SLPM<\/th>\n              <td>4<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\" colspan=\"2\">Current value<\/th>\n              <th>A<\/th>\n              <td>500<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\" colspan=\"2\">Spray distance<\/th>\n              <th>mm<\/th>\n              <td>100<\/td>\n            <\/tr>\n          <\/tbody>\n        <\/table>\n      <\/div><!-- \/.textcoutent -->\n      <div class=\"column_2\">\n        <h5 class=\"sub_title\" style=\"margin-bottom:0.5em;\"><span>Result<\/span><\/h5><!-- \/.sub_title -->\n        <div class=\"row img_row\" style=\"margin-top:0;\">\n            \n          <div class=\"textContent\">\n            <p class=\"table_title\">Microscopic image of coated film<\/p>\n            <table class=\"tablelist productlist productlis_img no_marginBottom\">\n              <tr>\n                <th>Before coating<\/th>\n                <th>After coating<\/th>\n              <\/tr>\n              <tr>\n                <td><img decoding=\"async\" style=\"max-height: 180px;\" src=\"\/home\/wp-content\/uploads\/2022\/05\/coating-before.jpg\" alt=\"Before coating\"><\/td>\n                <td><img decoding=\"async\" style=\"max-height: 180px;\" src=\"\/home\/wp-content\/uploads\/2022\/05\/coating-after.jpg\" alt=\"After coating\"><\/td>\n              <\/tr>\n            <\/table>\n          <\/div><!-- \/.textContent -->\n          <div class=\"textContent\">\n            <p class=\"table_title\">Cross-sectional image of coated film<\/p>\n            <table class=\"tablelist productlist productlis_img no_marginBottom\">\n              <tr>\n                <th>Magnification<\/th>\n                <th>Hydroxyapatite FP<\/th>\n                <th>Competitor Product<\/th>\n              <\/tr>\n              <tr>\n                <th>\u00d7200<\/th>\n                <td><img decoding=\"async\" src=\"\/home\/wp-content\/uploads\/2022\/05\/crosssection-hydroxyapatite-fp.png\" alt=\"Hydroxyapatite FP\"><\/td>\n                <td><img decoding=\"async\" src=\"\/home\/wp-content\/uploads\/2022\/05\/crosssection-competitor.png\" alt=\"Competitor Product\"><\/td>\n              <\/tr>\n            <\/table>  \n          <\/div><!-- \/.textContent -->\n        <\/div><!-- \/.row -->\n        <p>Our hydroxyapatite FP formed a film on the PEEK surface in a uniformly melted state.<br>In contrast, the competitor product failed to form a film.<\/p>\n      <\/div><!-- \/.column_2 -->\n <div class=\"textContent\">\n        <p class=\"table_title\">Characteristics of Coating Film<\/p>\n        <table class=\"tablelist productlist productlist7\" style=\"max-width:950px;\">\n          <thead>\n            <tr class=\"tr1\">\n              <th colspan=\"3\" class=\"text_center\">Test case<\/th>\n              <th class=\"text_center\">Result<\/th>\n            <\/tr>\n          <\/thead>\n          <tbody>\n            <tr>\n              <th class=\"th1 row_center\" rowspan=\"6\" style=\"text-align: left;\">Purity<\/th>\n              <th class=\"th2\" colspan=\"2\">Crystallinity<\/th>\n              <td>63%<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th2 row_center\" rowspan=\"4\">Impurity Phase<\/th>\n              <th >\u03b1-TCP<\/th>\n              <td>1.40%<\/td>\n            <\/tr>\n            <tr>\n              <th>\u03b2-TCP<\/th>\n              <td>1.60%<\/td>\n            <\/tr>\n            <tr>\n              <th>TTCP<\/th>\n              <td>1.00%<\/td>\n            <\/tr>\n            <tr>\n              <th>CaO<\/th>\n              <td>0.20%<\/td>\n            <\/tr>\n            <tr>\n              <th colspan=\"2\">Ca\/P ratio<\/th>\n              <td>1.67<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th1 row_center\" rowspan=\"4\" style=\"text-align: left;\">Characteristics<\/th>\n              <th class=\"th2\" colspan=\"2\">Vickers hardness<\/th>\n              <td>244 (HV0.3)<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th2\" colspan=\"2\">Abrasion<\/th>\n              <td>4.2 mg<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th2\" colspan=\"2\">Film thickness<\/th>\n              <td>170 um<\/td>\n            <\/tr>\n            <tr>\n              <th class=\"th2\" colspan=\"2\">Surface roughness (Ra)<\/th>\n              <td>4.1 um<\/td>\n            <\/tr>\n            \n          <\/tbody>\n        <\/table>\n<p>Hydroxyapatite FPs showed little decomposition to impurity phase after thermal spraying and formed a high-strength film.<br>Therefore, it showed desirable properties as a surface coating material for medical equipment.<\/p>\n      <\/div><!-- \/.textContent -->\n<\/div><!-- \/.contentBox -->\n\n\n\n<section class=\"btn__return_box\">\n  <a class=\"btn__return\" href=\"https:\/\/tomitaph.co.jp\/en\/products\/list\" target=\"_blank\" rel=\"noopener\">Back<\/a>\n<\/section>\n\n\n\n<\/article>\n        <!--\/l-mainbase -->\n      <\/div>\n      <\/section>\n      <\/div>\n    <\/article>\n   \n  <\/main>\n<\/div>\n<!--id=\"luxy\"-->\n\n\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biomaterials Hydroxyapatite Inorganic materials for the biomaterials field Hydroxyapatite Hydroxyapatite is basic calcium phosphate and exists naturally as a major component of bones and teeth and as an ore in nature. Hydroxyapatite shows high biocompatibility and is utilized in biomaterials such as artificial bones, dental implants, and coating materials for artificial joints. Tomita Pharmeceuticals&#8217; hydroxyapatite\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":914,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-915","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/pages\/915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/comments?post=915"}],"version-history":[{"count":23,"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/pages\/915\/revisions"}],"predecessor-version":[{"id":6489,"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/pages\/915\/revisions\/6489"}],"up":[{"embeddable":true,"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/pages\/914"}],"wp:attachment":[{"href":"https:\/\/tomitaph.co.jp\/en\/wp-json\/wp\/v2\/media?parent=915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}