{"id":918,"date":"2022-04-29T16:39:39","date_gmt":"2022-04-29T07:39:39","guid":{"rendered":"https:\/\/tomitaph.co.jp\/home\/products\/florite\/"},"modified":"2025-06-12T11:04:44","modified_gmt":"2025-06-12T02:04:44","slug":"florite","status":"publish","type":"page","link":"https:\/\/tomitaph.co.jp\/en\/products\/florite\/","title":{"rendered":"FLORITE™ Series of Multifunctional Excipients"},"content":{"rendered":"\n
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FLORITE™ Series of Multifunctional Excipients<\/h1>\n

FLORITE™ offers many advantages for various applications such as pharmaceuticals, food, cosmetics, and other industrial uses.<\/h2>\n

FLORITE™ is an inorganic functional material with a unique crystalline structure. It is a multifunctional powder with amazing water and oil absorption properties and excellent moldability.
\n\t\t\t\tIt has a petal-like structure* not found in other calcium silicates and has deep, large pores. Unlike ordinary porous materials, it therefore has an extremely large pore radius and pore volume.
\n\t\t\t\tSubstances can move relatively freely within these pores and can be used for adsorption, loading, release, and reaction of substances.
\n\t\t\t\tIn addition to its use as an adsorbent carrier and compacting agent, FLORITE™ can be used for stabilization applications and elution control of active ingredients.
\n*It differs depending on the item.<\/small>\n<\/p>\n \n

Key Features<\/h4>\n
\n\t\t\t\t\t
\n\t\t\t\t\t\t
Liquid Absorbency<\/dt>\n\t\t\t\t\t\t
Absorb fivefold* amount of liquid of own weight for alteration to powder form
*It differs depending on the item.<\/small>\n\t\t\t\t\t\t<\/dd>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t
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Compressibility<\/dt>\n\t\t\t\t\t\t
Boost tablet hardness in the tableting process, even with a lower tableting pressure. Decrease the risk of compressing troubles such as lamination. Realize direct compression.<\/dd>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t
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Improve Disintegration Speed of Tablets<\/dt>\n\t\t\t\t\t\t
Realize high disintegration speed by absorbing water inside of tablets even with high hardness<\/dd>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t
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Stabilizing Capability<\/dt>\n\t\t\t\t\t\t
Protect loading API in the macropore from light and oxygen<\/dd>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t
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Release Control<\/dt>\n\t\t\t\t\t\t
Increase the dissolution rate of API and fragrance. In the macropore by combination use with polymer for coating<\/dd>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t
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Solid Dispersion<\/dt>\n\t\t\t\t\t\t
Improve the release property of poorly water-soluble APIs in the macropore by amorphization<\/dd>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/dl>\n
\n \"Unique\n*FLORITE™ PS-10 and FLORITE™ A1 have different structures.<\/small>\n <\/div>\n <\/section>\n\n\n\n
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Liquid Absorbency<\/span><\/h4>\n
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Unlike the pore structure of any other porous material, FLORITE™’s unique petaloid crystal structure forms macropores with a large colume within the particle. These macropores are the key factor for the absorbing capacity.
\n\t\t FLORITE™ has the ability to absorb and retain an amount of liquid which is approximately five times its own weight. The macropores develop deeply in the vertical direction, and thus the openings of these pores have small areas compared to their volumes. This protects the liquid in the pores from being affected by oxygen, vaper, or other elements in the external environment.<\/p>\n <\/div>\n

\n \n \"Comparison\n <\/div>\n <\/div>\n

FLORITE™ has the ability to absorb and retain an amount of liquid which is approximately five times* its own weight.
*It differs depending on the item.<\/small><\/p>\n <\/div>\n\n \n<\/div>\n\n\n\n

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Improvement of compressibility and disintegration speed of tablets<\/span><\/h4>\n
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In the compression process, the crystal stracture of FLORITE™ is easily broken at low pressure, and each petaloid structure binds together strongly to exhibit superior binding capability. It can achieve the necessary hardness with minimal pressure, by adding FLORITE™ to your formulation.
\nIn addition, it suppresses the lamination of tablets and longer disintegration times caused by high striking pressure and also reduces damage not only to the mortar and pestle but also to the main body of the tableting machine.
\nIt improves the moldability of tablets, and depending on the formulation, it can be manufactured by a direct tableting method excluding the granulation process.<\/p>\n<\/div>\n

\n
\n \"Compressibility\n <\/div>\n\n
\n \n \n \n \n\n \n \n \n \n \n \n
Raw material<\/th>\n Assay<\/th>\n <\/tr>\n
Acetaminophen<\/td>\n 22.6 mg<\/td>\n <\/tr>\n
Binder(Any one of them)\n
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  • FLORITE™ R<\/li>\n
  • FLORITE™ PS-200<\/li>\n
  • Granulated Lactose<\/li>\n
  • Microcrystalline Cellulose<\/li>\n
  • Dibasic Calcium Phosphate,
    Anhydrous<\/li>\n <\/ul>\n <\/td>\n
90.2 mg<\/td>\n <\/tr>\n
Crospovidone<\/td>\n 6.6 mg<\/td>\n <\/tr>\n \n
Magnesium Stearate<\/td>\n 0.6 mg<\/td>\n <\/tr>\n \n
Total<\/td>\n 120 mg<\/td>\n <\/tr>\n \n <\/tbody>\n <\/table>\n <\/div>\n \n <\/div>\n\n<\/div>\n

A powerful binding performance is exhibited at even low compression forces,
and it reaches the preferred tablet hardness with less than half the compression force of the other binder.<\/p>\n<\/div>\n\n\n\n

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Product List<\/span><\/h4>\n
\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n
Product<\/th>\n FLORITE™ R<\/td>\n FLORITE™ PS-200*4<\/span><\/td>\n FLORITE™ PS-10<\/td>\n\t\n <\/tr>\n
Chemical name<\/th>\n Calcium Silicate<\/td>\n\t\n <\/tr>\n
Appearance<\/th>\n White, Powder<\/td>\n White, Fine granule<\/td>\n White, Fine Powder<\/td>\n\t\n <\/tr>\n
Crystal structure<\/th>\n Petaloid<\/td>\n Petaloid<\/td>\n –<\/td>\n\t\n <\/tr>\n
Oil absorbing capacity (mL\/g)<\/th>\n 4.6<\/td>\n 4.8<\/td>\n 3.2<\/td>\n\t\n <\/tr>\n\n
Loose bulk density (g\/mL)<\/span><\/th>\n 0.07<\/td>\n 0.07<\/td>\n 0.09<\/td>\n\t\n <\/tr>\n
Tapped bulk density (g\/mL)<\/span><\/th>\n 0.11<\/td>\n 0.10<\/td>\n 0.15<\/td>\n\t\n <\/tr>\n
Loose bulk specific volume (mL\/g)<\/span><\/th>\n 14.4<\/td>\n 13.7<\/td>\n 11.0<\/td>\n\t\n <\/tr>\n
Tapped bulk specific volume (mL\/g)<\/span><\/th>\n 8.8<\/td>\n 10.3<\/td>\n 6.6<\/td>\n\t\n <\/tr>\n
Particle size D50 (\u00b5m)<\/span><\/th>\n 30<\/td>\n 130<\/td>\n 10<\/td>\n\t\n <\/tr>\n
Repose angle (\u00b0)<\/span><\/th>\n 47<\/td>\n 40<\/td>\n 56<\/td>\n\t\n <\/tr>\n
pH<\/th>\n 9<\/td>\n 9<\/td>\n 10<\/td>\n\t\n <\/tr>\n
Specific surface(m2<\/span>\/g)<\/span><\/th>\n 160<\/td>\n 200<\/td>\n 230<\/td>\n\t\n <\/tr>\n
Regulation status<\/th>\n \n
    \n
  • JPE*1<\/span><\/li>\n
  • JSFA*2<\/span><\/li>\n
  • NF*3<\/span><\/li>\n <\/ul>\n <\/td>\n
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    \n
  • JPE<\/li>\n
  • NF<\/li>\n\t\t\t<\/ul>\n\t\t <\/td>\n
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